RNAi Controls
Invitrogen™ Silencer™ Negative Control No. 4 siRNA
Ambion™ Silencer™ Negative Control #4 siRNA has no significant sequence similarity to mouse, rat, or human gene sequences.
Invitrogen™ Ambion™ In Vivo Factor VII Positive Control siRNA
Ambion™ In Vivo siRNAs are designed using the proven Silencer™ Select algorithm and incorporate chemical modifications for superior serum stability with in vivo delivery.
HORIZON DISCOVERY BIOSCIENCES LIMITED SMARTVECTOR LENTIVIRAL CONTROL
SMARTvector Lentiviral Controls, Control 1, hCMV, TurboGFP, lentiviral particles, 50ul
Genscript Corporation CD3ECD3D hFc Chimera Biotin
T-cell surface glycoprotein CD3 epsilon CD3 delta chain also known as CD3E CD3D are single-pass type I membrane proteins When antigen presenting cells (APCs) activate T-cell receptor (TCR) TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D CD3E CD3G and CD3Z All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain
Genscript Corporation CD98 hFc Chimera Human
The type II transmembrane protein CD98 best known as the heavy chain of the heterodimeric amino acid transporters (HAT) is required for the surface expression and basolateral localization of this transporter complex in polarized epithelial cells CD98 also interacts with beta1 integrins resulting in an increase in their affinity for ligand In this study we explored the role of the transmembrane and cytoplasmic domains of CD98 on integrin-dependent cell adhesion and migration in polarized renal epithelial cells
Genscript Corporation SLAMF7/CRACC/CD319 mFc Chimera
CD2-like receptor activating cytotoxic cells (CRACC) also known as CS1 novel Ly9 SLAMF7 and CD319 is a 65-75 kDa type I transmembrane glycoprotein in the SLAM subgroup of the CD2 family Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response
Genscript Corporation CD96/TACTILE mFc Chimera Huma
The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells and recent studies suggest both play important inhibitory roles in immune function CD96 has been shown to modulate immune cell activity in mice with Cd96-/- mice displaying hypersensitive NK-cell responses to immune challenge and significant tumor resistance The counterbalance between the putative inhibitory CD96 and TIGIT receptors and the activating receptor CD226 offers unique strategies for immuno-oncology drug development
Genscript Corporation CD44 hFc Chimera Human
CD44 is a hyaluronan binding cell surface signal transducing receptor that influences motility cell survival and proliferation as well as the formation of tumor microenvironment CD44 contains two variable regions encoded by variable exons Alternative splicing which is often deregulated in cancer can produce various isoforms of CD44 with properties that may have different tissue specific effects and therefore even diverse effects on cancer progression
Genscript Corporation CD52 hFc Chimera Mouse
CD52 also known as CAMPATH-1 antigen HE5 and gp20 is a cell surface glycoprotein that can be targeted to induce immune suppression by complement-mediated cell lysis Mature human CD52 is a 12 amino acid peptide that is tethered to the cell surface with a GPI linkage CD52 may play a role in carrying and orienting carbohydrate as well as having a more specific role
Genscript Corporation NKG2D/CD314 hFc Chimera Flag
NKG2D is a type II transmembrane glycoprotein having an extracellular lectin-like domain This domain lacks the recognizable calcium-binding sites found in true C-type lectins and binds protein rather than carbohydrate ligands Human NKG2D is expressed on CD8 alpha beta T cells gamma T cells NK cells and NKT cells
Genscript Corporation GLP-1R mFc Chimera Human
The GLP1R a GPCR is found on pancreatic beta cells and brain neurons It regulates blood sugar by enhancing insulin secretion In humans it is encoded by the gene GLP1R on chromosome 6 GLP1R is part of the glucagon receptor GPCR family and comprises an extracellular domain that binds the C-terminal helix of GLP-1 and a transmembrane domain that binds the N-terminal region of GLP-1 The TMD domain contains polar residues that regulate biased signaling while the transmembrane helical boundaries and extracellular surface trigger biased agonism
Genscript Corporation CD160 hFc Chimera Mouse
CD160 (also Natural killer cell receptor BY55) is a 27 30 kDa member of the Ig superfamily In human it is expressed principally on nonmyeloid hematopoietic cells CD160 antigenis a receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation Exists as a GPI-anchored and as a transmembrane form each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells
Genscript Corporation CD98 hFc Chimera Human
The type II transmembrane protein CD98 best known as the heavy chain of the heterodimeric amino acid transporters (HAT) is required for the surface expression and basolateral localization of this transporter complex in polarized epithelial cells CD98 also interacts with beta1 integrins resulting in an increase in their affinity for ligand In this study we explored the role of the transmembrane and cytoplasmic domains of CD98 on integrin-dependent cell adhesion and migration in polarized renal epithelial cells